Join the FREE 30-Day PCOS Diet Challenge
Home / Blog / PCOS Weight Loss / How To Lose Weight With PCOS: 15 Science-Based Strategies

How To Lose Weight With PCOS: 15 Science-Based Strategies

Kym Campbell

By Kym Campbell, BSc. | Updated March 18th, 2024
Medically Reviewed by Dr. Sarah Lee, M.D & Dr. Jessica A McCoy, Ph.D

Comments (0)

Key Takeaways

PCOS women gain weight because of insulin resistance and chronic inflammation. To lose weight with PCOS you must address these underlying mechanisms.

Reduce sugar and improve intake of carbs, protein, and fat. Eat less inflammatory foods and more fiber and non-starchy vegetables.

Further optimize your diet with supplements, intuitive eating, fasting, and blood glucose monitoring.

Exercise, sleep, and stress management are all valuable treatments for PCOS.

All PCOS patients should be properly screened for thyroid dysfunction.

Get started with a PCOS diet by joining my free 30-Day PCOS Diet Challenge. If you aren’t ready to commit to 30 days try this free 3-Day Meal Plan instead.

Polycystic Ovary Syndrome (PCOS) affects around 1 in 10 women of childbearing age. More than half of these women are overweight [1]. While a PCOS diagnosis can feel like a constant struggle, weight loss of 5-10% can make a big difference [2-5]. Achieving a healthy weight helps with irregular periods, ovarian function, and unwanted hair. Other cardiovascular health markers are also improved. This includes things like insulin levels, visceral fat, high blood pressure, and more.

In this article, I explain the root causes of PCOS weight gain. I then share 15 important steps that can help you take back control of your health

To put these good ideas into practice, sign up for my free 30-Day PCOS Diet Challenge. You can also download my free 3-Day PCOS Meal Plan here.

The Cause Of PCOS Weight Gain

Losing weight with polycystic ovarian syndrome is easier said than done. PCOS women gain weight easier than people without PCOS [6] . We also have more trouble losing weight [7].

PCOS weight gain is caused by hormonal imbalances. But these imbalances stem from insulin resistance and chronic inflammation. Insulin resistance causes higher rates of body fat accumulation and plays a key role in weight management [8-10]. Chronic inflammation also drives weight gain [11]. This has a significant genetic component, but environmental influences like diet and lifestyle can turn this dial up and down.

Addressing these mechanisms provides the pathway for almost every PCOS weight loss intervention. It’s the underlying reason why the following 15 steps work and why I see so many women lose weight during my free 30-Day PCOS Diet Challenge. Improving insulin regulation and reducing inflammation is key to losing weight with PCOS.

1. Reduce Your Sugar Intake

Reducing sugar intake is the single most effective dietary intervention for PCOS. It’s one of the most important foods to avoid with PCOS.

Most natural sources of sugar contain approximately 50% fructose and 50% glucose. Both of these compounds can make you gain weight.

Fructose is problematic because it’s metabolized by the liver like a toxicant. Because of its comparable long-term effects on metabolic health, some experts call fructose “alcohol without the buzz” [12]. People used to think that over-eating high-fat foods caused weight gain. But current evidence now shows that fructose may be the biggest risk factor for obesity [13, 14] .

This is especially true for PCOS women. Research shows that overweight women with PCOS have high fructose levels [15]. Other studies indicate that high sugar intake is associated with greater belly fat [16]. These findings draw a straight line between reducing sugar intake and losing weight.

The glucose half of the sugar molecule can also be a problem for weight management. While essential for life, an overabundance of dietary glucose can increase body fat. This is because insulin resistance can develop when exposed to chronic energy surplus [17].

Candy and soda are obvious targets for elimination, but many food items contain “hidden” sugars too. This PCOS foods to avoid list includes a list of common sugar-rich foods. These are some of the food items that women with PCOS should be particularly cautious of. Getting in the habit of checking nutrition labels is an important habit if you want to lose weight.

2. Eat Slow Carb & Low Carb, From Whole Food Sources

Besides reducing sugar consumption, lowering glycemic load is a powerful way to lose weight with PCOS. Glycemic load describes the total effect of a meal on your blood sugar levels. It’s a combination of the glycemic index (GI), which describes how quickly a food raises blood sugar levels, and how much you consume. It’s a proxy for how much insulin you’ll need to digest a meal. By reducing glycemic load, the body requires less insulin. This, in turn, reduces body fat accumulation [18, 19].

The simplest way to lower the glycemic load of your meal is to:

  1. Choose foods that are relatively low GI i.e. “slow carbs”.
  2. Eat a small amount of carbohydrate-rich foods i.e. “low-carb”.
  3. Get your carbs from whole food sources. Processed foods can game the system by making low-GI foods that are full of fructose (fructose is low-GI).

Black rice, sweet potato, and quinoa are examples of relatively low GI, carbohydrate-rich whole foods. A “good” serving size for these foods is around half a cup (cooked). This is “low-carb” by most standards, but is enough to avoid ketosis. Discover the pros and cons of a keto diet for PCOS here.

For a comprehensive list of low-GI whole foods, download this PCOS Diet Cheat Sheet.

3. Consume Healthy Fats

Despite dietary fat being incorrectly blamed for increases in obesity [20] , eating more fat can help with weight loss.

For a start, fat consumption has a positive effect on satiety and appears to regulate appetite [21]. Some of the fats, found in beef and lamb, can improve glucose tolerance, increase insulin sensitivity [22, 23], and reduce body fat [24, 25].

Coconut food products are also particularly useful for weight loss. These foods tend to be rich in medium-chain triglycerides which promote fat loss from the stomach and thigh areas [26, 27].

Oily fish, nuts, seeds, olive oil, and avocado are rightly promoted as “healthy” fats. But, saturated fats from whole foods sources are also good for PCOS.

Randomized controlled trials show that saturated fat doesn’t increase heart disease risks [28]. As a result, many experts now oppose the US Dietary Guidelines for Americans recommendation to limit saturated fats. Nearly 20 papers published within the past 10 years, review the totality of data on saturated fat and cardiovascular outcomes. These papers show that the recommendation to limit saturated fats lacks scientific rigor [29].

A list of recommended fats and oils can be found here in my PCOS Diet Cheat Sheet.

4. Get Enough Protein

Dietary protein impacts weight loss in several ways. It influences satiety, heat production, energy efficiency, and body composition.

In an article published in the American Journal of Clinical Nutrition, Dr. Paddon-Jones, and colleagues [30] explain that:

  • Protein increases satiety to a greater extent than carbohydrate or fat consumption.
  • Higher protein diets are associated with increased heat production. This helps you burn calories faster.
  • Higher protein diets favor the retention of muscle mass over fat.

Animal-derived protein from meat, eggs, and seafood is best. These are “complete” protein sources containing all essential amino acids in a bioavailable form. Unlike most plant-derived protein sources, animal protein is also much lower in carbohydrates and higher in fat.

My PCOS Diet Cheat Sheet includes a list of recommended protein-rich foods.

5. Eat High Fiber Foods

The nuances of a healthy diet are debatable. But almost all experts agree that eating more dietary fiber helps with weight loss [31].

Studies show that obesity in women with PCOS can’t be explained by overeating or inactivity. But, women with PCOS tend to consume less fiber [32]. Even small reductions in dietary fiber intake may increase abdominal fat in higher-risk individuals [33]. Because fiber consumption impacts insulin resistance [34], eating more fiber-rich foods is key to any PCOS weight loss diet.

Some of the best high-fiber foods include garlic, artichoke, avocado, crucifers, and starchy vegetables. Passionfruit, pomegranate, blackberries, and raspberries are also rich in dietary fiber.

6. Eat Non-Starchy Vegetables

Non-starchy vegetables are a key recommendation for PCOS weight loss. This is especially true for vegetables that are dark green and deep orange/yellow. These foods provide essential micronutrients for sustaining good health. They also improve insulin regulation, which helps with weight loss [35, 36].

7. Avoid Inflammatory Foods

Insulin resistance causes the accumulation of body fat. But for women with PCOS, chronic inflammation is another cause of weight gain [37]. Inflammation is one of the root causes of all PCOS symptoms and can be caused by a wide range of environmental factors.

Diet is a key environmental input. Reducing foods that drive inflammation can not only help with weight loss but may also improve the entire spectrum of PCOS symptoms.

Common ways that diet can induce inflammation include:

  1. The over-consumption of readily available carbohydrates, especially sugar.
  2. Consumption of pro-inflammatory foods, especially vegetable oils, and processed foods.
  3. Foods that induce an allergic response.
  4. Foods where a subclinical intolerance may be present.

Of this last category, gluten and dairy tend to be the most common among women with PCOS. These ingredients are often the primary drivers of weight gain. Elimination of gluten and dairy has played a key role in the success of thousands of women that have completed my 30-Day PCOS Diet Challenge.

8. Follow Your Hunger & Fullness Cues

Ironically, traditional dieting methods can be counterproductive to women with PCOS. Restriction diets that control calorie intake, often fail over the long run. Studies have shown that in the majority of cases, dieting causes weight gain rather than weight loss [38].

Add to this, the fact that PCOS is associated with high rates of disordered eating [39, 40], and you have a perfect recipe for disappointment.

Intuitive eating is a more realistic approach for long-term weight maintenance [41-43]. It’s particularly helpful for people that have struggled with binge eating in the past.

Intuitive eating recognizes that people can naturally regulate their caloric intake. Charts, calculations, and apps simply aren’t needed. This innate ability comes from hunger and fullness signaling hormones, like ghrelin and leptin [44]. These hormones respond well to a diet that’s high in protein and vegetables [45-49]. This is another reason why a whole-food-based PCOS diet is best for weight loss. You feel less hungry and more satisfied.

The Intuitive Eating Module included in my Beat PCOS 10 Week Program is especially popular for women that want to lose weight. As many participants discover, losing weight is as much about fostering a healthy relationship with food as it is about nutrition. To break free from yo-yo dieting, it’s essential to overcome the negative psychological impact of previous diets. We need to follow our natural hunger and fullness cues instead.

9. Consider Intermittent Fasting

Intermittent fasting is a viable tool for improving metabolic health and weight loss [50, 51]. Studies show that limiting the time in which food is consumed has potential benefits for PCOS. This includes better body composition, insulin sensitivity, menstruation, chronic inflammation, and androgen regulation [52].

Learn more about intermittent fasting for PCOS here.

10. Check Blood Glucose Levels

A low-carb diet drives weight loss by reducing blood glucose levels. This reduces the recruitment of insulin, which tends to store excess glucose as fat.

Blood glucose levels depend on many circumstances that change from day to day. The most important is the type and quantity of dietary carbohydrates. Total meal composition, sleep, stress, and exercise, also alter the glycemic response of any given meal.

By measuring and monitoring blood glucose levels, it’s possible to further optimize your diet for weight loss. What you want to see is a slow rise in blood sugars after you eat. A peak of less than 110 mg/dL (6.1 mmol/L) is good. This can be measured using a flash glucose monitor which samples a finger prick of blood. This type of monitor gives you a single snapshot in time. Continuous blood glucose monitors, by comparison, provide a more complete picture. These are the best devices for understanding how diet and lifestyle decisions impact weight loss.

Abbott and Dexcom are the leading suppliers of continuous glucose monitoring systems.

11. Supplement Your Diet

Many dietary supplements can help women with PCOS lose weight. While weight loss benefits tend to be small, Myo-inositol or Ovasitol are the most popular. This naturally occurring nutrient is safe and effective at improving insulin sensitivity. This, in turn, produces modest weight loss [53-55]. Studies have shown that Myo-inositol is as effective as metformin [78]. Read my article on inositol and PCOS for more about this supplement.

Many other nutritional supplements for weight loss that may be worth discussing with your doctor. Top of the list for women with PCOS are berberine [56] and magnesium [77]. It’s also worth considering zinc [57] , calcium + Vitamin D [58] , carnitine [59] , selenium [60], and chromium [61].

12. Exercise Frequently

Research shows how physical activity improves insulin sensitivity and body composition in women with PCOS [62, 63]. The best types of exercise for PCOS generally fall into one of two main categories. Aerobic exercise and resistance training. Aerobic exercise reduces inflammation [64]. Resistance training, by comparison, improves hormone regulation [65].

13. Reduce Your Stress Levels

Stress indirectly affects body weight through a variety of mechanisms [66]. It influences our eating behaviors and self-control. It makes us hungrier and causes carb cravings. Stress also makes us less active and reduces how much we sleep (see below).

Stress is a risk factor for even the healthiest individuals, but women with PCOS experience more stress than other people without PCOS [67]. This presents both a problem and an opportunity. On the one hand, women with PCOS need to be more mindful of managing their stress levels. On the other, any intervention that reduces stress is likely to aid in weight loss.

Some of the best stress-management tools include mindfulness meditation, relaxation exercises, and cognitive behavioral therapy. Physical activity is also a powerful way to reduce anxiety and depressive symptoms [68].

14. Improve Your Sleep

In case feeling great isn’t enough to motivate better sleep habits, improving sleep can also help with weight loss:

  • Sleep reduces stress [69] (see above).
  • Poor quality sleep is associated with systemic inflammation [70], a primary cause of PCOS weight gain.
  • Sleep apnea impacts insulin resistance and glucose tolerance in women with PCOS [71, 72].
  • Inadequate sleep quality influences eating habits [73].
  • Getting more sleep reduces preferences for sugary foods [74].

Overcoming insomnia can be a significant challenge for many people. But there are many ways to improve sleep quality. Things like prioritizing an early bedtime, and reducing blue light exposure in the evenings. Relaxation exercises and sleep meditations can also make a positive impact on weight loss.

15. Get Your Thyroid Checked (Properly)

Thyroid dysfunction affects women with PCOS at roughly three times the rate found in non-PCOS populations. A large percentage of these cases are undiagnosed [75]. When left untreated, subclinical hypothyroidism presents a significant barrier to weight loss.

Thyroid dysfunction can be particularly difficult to diagnose in many women with PCOS. For example, the elevated androgen levels seen in PCOS can decrease thyroxine-binding globulin (TBG) [76]. Thyroid dysfunction will be missed if only TSH and free T4 are assessed. These biomarkers can show up as normal, despite there being an underlying issue. A proper diagnosis is only possible with a full thyroid panel. This should include TBG, T3, reverse T3, and thyroid antibodies (TPOAb and TGAb).

Anyone wanting to lose weight with PCOS should get a full thyroid panel test. This is especially important if the benefits of diet and lifestyle interventions appear to be limited.

The Bottom Line

For many women, having PCOS means it’s easy to gain weight and hard to lose it. But despite the added barriers to weight loss, it’s certainly possible with the right information and support.

Hundreds of thousands of PCOS women have started losing weight using the free resources available on this website. If you’re ready to take back control of your health then join me for my free 30-Day PCOS Diet Challenge.

During this event, you’ll put into practice many of the weight loss ideas described in this blog. The Challenge includes free weekly meal plans and helpful video lessons. It’s hosted within a vibrant community of like-minded women and has been the starting point for many PCOS weight loss success stories.

If you aren’t ready to try the full 30 days, you can get started with this free 3-Day Meal Plan.

Ready to Take Action?

  • Join my free 30-Day PCOS Diet Challenge here. This is a unique program where you'll receive weekly meal plans, shopping lists, and helpful video lessons. You'll also be part of a motivated and inspiring community of like-minded women.

  • Download my free 3-Day PCOS Diet Meal Plan here. This is perfect for getting started if you aren't ready to commit to 30 days.

  • Join my PCOS Monthly Meal Planning Service here. This service includes hundreds of PCOS recipes within a pre-populated, yet customizable meal plan. It's designed to save you time and help you apply a PCOS diet.

  • Sign up for my Beat PCOS 10-Week Program. This is a comprehensive program that covers diet, PCOS-centric emotional eating, exercise, stress management, and much more. All within a support group environment. The 10-Week Program includes the same recipes and meal plan as my monthly meal planning service.



Back to Top


1Deswal, R., et al., The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. J Hum Reprod Sci, 2020. 13(4): p. 261-271.

2Thomson, R.L., et al., The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab, 2008. 93(9): p. 3373-80.

3Stamets, K., et al., A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril, 2004. 81(3): p. 630-7.

4Tolino, A., et al., Evaluation of ovarian functionality after a dietary treatment in obese women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol, 2005. 119(1): p. 87-93.

5Kuchenbecker, W.K., et al., In women with polycystic ovary syndrome and obesity, loss of intra-abdominal fat is associated with resumption of ovulation. Hum Reprod, 2011. 26(9): p. 2505-12.

6Sam, S., Obesity and Polycystic Ovary Syndrome. Obes Manag, 2007. 3(2): p. 69-73.

7Lim, S., et al., Barriers and facilitators to weight management in overweight and obese women living in Australia with PCOS: a qualitative study. BMC Endocr Disord, 2019. 19(1): p. 106.

8Zeng, X., et al., Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta, 2020. 502: p. 214-221.

9Bannigida, D.M., B.S. Nayak, and R. Vijayaraghavan, Insulin resistance and oxidative marker in women with PCOS. Arch Physiol Biochem, 2020. 126(2): p. 183-186.

10Petersen, M.C. and G.I. Shulman, Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev, 2018. 98(4): p. 2133-2223.

11Rudnicka, E., et al., Chronic Low Grade Inflammation in Pathogenesis of PCOS. Int J Mol Sci, 2021. 22(7).

12Lustig, R.H., Fructose: it’s “alcohol without the buzz”. Adv Nutr, 2013. 4(2): p. 226-35.

13Softic, S., et al., Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci, 2020. 57(5): p. 308-322.

14Dornas, W.C., et al., Health implications of high-fructose intake and current research. Adv Nutr, 2015. 6(6): p. 729-37.

15Shi, B., et al., Fructose levels are elevated in women with polycystic ovary syndrome with obesity and hyperinsulinemia. Hum Reprod, 2020. 35(1): p. 187-194.

16Gyllenhammer, L.E., et al., Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth. Obesity (Silver Spring), 2014. 22(2): p. 474-81.

17Samuel, V.T. and G.I. Shulman, The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest, 2016. 126(1): p. 12-22.

18Maki, K.C., et al., Effects of a reduced-glycemic-load diet on body weight, body composition, and cardiovascular disease risk markers in overweight and obese adults. Am J Clin Nutr, 2007. 85(3): p. 724-34.

19Pereira, M.A., et al., Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. Jama, 2004. 292(20): p. 2482-90.

20Bray, G.A., S. Paeratakul, and B.M. Popkin, Dietary fat and obesity: a review of animal, clinical and epidemiological studies. Physiol Behav, 2004. 83(4): p. 549-55.

21Samra, R.A., Frontiers in Neuroscience Fats and Satiety, in Fat Detection: Taste, Texture, and Post Ingestive Effects, J.P. Montmayeur and J. le Coutre, Editors. 2010, CRC Press/Taylor & Francis Copyright © 2010, Taylor & Francis Group, LLC.: Boca Raton (FL).

22Ryder, J.W., et al., Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes, 2001. 50(5): p. 1149-57.

23Castro-Webb, N., E.A. Ruiz-Narváez, and H. Campos, Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes. Am J Clin Nutr, 2012. 96(1): p. 175-81.

24Blankson, H., et al., Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr, 2000. 130(12): p. 2943-8.

25Kennedy, A., et al., Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem, 2010. 21(3): p. 171-9.

26Mumme, K. and W. Stonehouse, Effects of medium-chain triglycerides on weight loss and body composition: a meta-analysis of randomized controlled trials. J Acad Nutr Diet, 2015. 115(2): p. 249-263.

27St-Onge, M.P. and P.J. Jones, Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr, 2002. 132(3): p. 329-32.

28Hamley, S., The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials. Nutr J, 2017. 16(1): p. 30.

29Astrup, A., et al., Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based? Nutrients, 2021. 13(10).

30Paddon-Jones, D., et al., Protein, weight management, and satiety. Am J Clin Nutr, 2008. 87(5): p. 1558s-1561s.

31Marsh, K. and J. Brand-Miller, The optimal diet for women with polycystic ovary syndrome? Br J Nutr, 2005. 94(2): p. 154-65.

32Cutler, D.A., S.M. Pride, and A.P. Cheung, Low intakes of dietary fiber and magnesium are associated with insulin resistance and hyperandrogenism in polycystic ovary syndrome: A cohort study. Food Sci Nutr, 2019. 7(4): p. 1426-1437.

33Davis, J.N., et al., Inverse relation between dietary fiber intake and visceral adiposity in overweight Latino youth. Am J Clin Nutr, 2009. 90(5): p. 1160-6.

34Weickert, M.O. and A.F.H. Pfeiffer, Impact of Dietary Fiber Consumption on Insulin Resistance and the Prevention of Type 2 Diabetes. J Nutr, 2018. 148(1): p. 7-12.

35Gołąbek, K.D. and B. Regulska-Ilow, Dietary support in insulin resistance: An overview of current scientific reports. Adv Clin Exp Med, 2019. 28(11): p. 1577-1585.

36Cook, L.T., et al., Vegetable consumption is linked to decreased visceral and liver fat and improved insulin resistance in overweight Latino youth. J Acad Nutr Diet, 2014. 114(11): p. 1776-83.

37González, F., Inflammation in Polycystic Ovary Syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids, 2012. 77(4): p. 300-5.

38Mann, T., et al., Medicare’s search for effective obesity treatments: diets are not the answer. Am Psychol, 2007. 62(3): p. 220-33.

39Lee, I., et al., Increased risk of disordered eating in polycystic ovary syndrome. Fertil Steril, 2017. 107(3): p. 796-802.

40Paganini, C., et al., The Overlap Between Binge Eating Behaviors and Polycystic Ovarian Syndrome: An Etiological Integrative Model. Curr Pharm Des, 2018. 24(9): p. 999-1006.

41Cadena-Schlam, L. and G. López-Guimerà, Intuitive eating: an emerging approach to eating behavior. Nutr Hosp, 2014. 31(3): p. 995-1002.

42Fuentes Artiles, R., et al., Mindful eating and common diet programs lower body weight similarly: Systematic review and meta-analysis. Obes Rev, 2019. 20(11): p. 1619-1627.

43Van Dyke, N. and E.J. Drinkwater, Relationships between intuitive eating and health indicators: literature review. Public Health Nutr, 2014. 17(8): p. 1757-66.

44Yeung, A.Y. and P. Tadi, Physiology, Obesity Neurohormonal Appetite And Satiety Control, in StatPearls. 2021, StatPearls Publishing Copyright © 2021, StatPearls Publishing LLC.: Treasure Island (FL).

45Teff, K.L., et al., Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab, 2004. 89(6): p. 2963-72.

46Ma, X., et al., Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutr Diabetes, 2013. 3(12): p. e99.

47Blom, W.A., et al., Effect of a high-protein breakfast on the postprandial ghrelin response. Am J Clin Nutr, 2006. 83(2): p. 211-20.

48Lejeune, M.P., et al., Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr, 2006. 83(1): p. 89-94.

49Gannon, M.C. and F.Q. Nuttall, Effect of a high-protein diet on ghrelin, growth hormone, and insulin-like growth factor-I and binding proteins 1 and 3 in subjects with type 2 diabetes mellitus. Metabolism, 2011. 60(9): p. 1300-11.

50Kang, J., et al., Effect of Time-Restricted Feeding on Anthropometric, Metabolic, and Fitness Parameters: A Systematic Review. J Am Coll Nutr, 2021: p. 1-16.

51Adafer, R., et al., Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health. Nutrients, 2020. 12(12).

52Li, C., et al., Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. J Transl Med, 2021. 19(1): p. 148.

53Nordio, M. and E. Proietti, The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol Sci, 2012. 16(5): p. 575-81.

54Gerli, S., et al., Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci, 2007. 11(5): p. 347-54.

55Le Donne, M., et al., Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome. Eur Rev Med Pharmacol Sci, 2019. 23(5): p. 2293-2301.

56Rondanelli, M., et al., Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Arch Gynecol Obstet, 2020. 301(1): p. 53-60.

57Foroozanfard, F., et al., Effects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Exp Clin Endocrinol Diabetes, 2015. 123(4): p. 215-20.

58Asemi, Z., et al., Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clin Nutr, 2015. 34(4): p. 586-92.

59Samimi, M., et al., Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf), 2016. 84(6): p. 851-7.

60Jamilian, M., et al., Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf), 2015. 82(6): p. 885-91.

61Fazelian, S., et al., Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. J Trace Elem Med Biol, 2017. 42: p. 92-96.

62Almenning, I., et al., Effects of High Intensity Interval Training and Strength Training on Metabolic, Cardiovascular and Hormonal Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Study. PLoS One, 2015. 10(9): p. e0138793.

63Cheema, B.S., L. Vizza, and S. Swaraj, Progressive resistance training in polycystic ovary syndrome: can pumping iron improve clinical outcomes? Sports Med, 2014. 44(9): p. 1197-207.

64Covington, J.D., et al., Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise. Biochimie, 2016. 124: p. 27-33.

65Kogure, G.S., et al., Resistance Exercise Impacts Lean Muscle Mass in Women with Polycystic Ovary Syndrome. Med Sci Sports Exerc, 2016. 48(4): p. 589-98.

66Tomiyama, A.J., Stress and Obesity. Annu Rev Psychol, 2019. 70: p. 703-718.

67Benson, S., et al., Disturbed stress responses in women with polycystic ovary syndrome. Psychoneuroendocrinology, 2009. 34(5): p. 727-35.

68Wegner, M., et al., Effects of exercise on anxiety and depression disorders: review of meta- analyses and neurobiological mechanisms. CNS Neurol Disord Drug Targets, 2014. 13(6): p. 1002-14.

69Sin, N.L., et al., Sleep duration and affective reactivity to stressors and positive events in daily life. Health Psychol, 2020. 39(12): p. 1078-1088.

70Irwin, M.R., R. Olmstead, and J.E. Carroll, Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry, 2016. 80(1): p. 40-52.

71Tasali, E., et al., Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome. J Clin Endocrinol Metab, 2008. 93(10): p. 3878-84.

72Van Cauter, E., Sleep disturbances and insulin resistance. Diabet Med, 2011. 28(12): p. 1455-62.

73Blumfield, M.L., et al., Dietary disinhibition mediates the relationship between poor sleep quality and body weight. Appetite, 2018. 120: p. 602-608.

74Al Khatib, H.K., et al., Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomized controlled pilot study. Am J Clin Nutr, 2018. 107(1): p. 43-53.

75Garelli, S., et al., High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013. 169(2): p. 248-251.

76Refetoff, S., Thyroid Hormone Serum Transport Proteins, in Endotext, K.R. Feingold, et al., Editors. 2000,, Inc. Copyright © 2000-2021,, Inc.: South Dartmouth (MA).

77Farsinejad-Marj, M., et al., Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome. Biol Trace Elem Res, 2020. 196(2): p. 349-358.

78Facchinetti, F., et al., Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials. Gynecol Endocrinol, 2019. 35(3): p. 198-206.


Leave a Comment