Key Takeaways
You’re about to gain some unique insight on how to use Berberine to manage your PCOS. As a Nutritionist, I’ve used evidence-based diet and lifestyle interventions to help over 100,000 women with this syndrome.
When coupled with a PCOS diet like the one used in my free 30-Day PCOS Diet Challenge, berberine can be a valuable addition to a healthy lifestyle.
Benefit 1: Berberine Treats PCOS Through Many Pathways
There are three underlying mechanisms driving all PCOS symptoms. Insulin resistance, chronic inflammation, and elevated androgens. These factors cause PCOS weight gain and infertility. They also cause other common PCOS symptoms like acne, hirsutism, hair loss, anxiety, and depression.
Berberine is a natural plant extract that can address all three mechanisms of PCOS. It primarily addresses insulin resistance. But it also reduces inflammation and decreases androgen levels [1]. This can add up to many potential health benefits [13].
Benefit 2: It Can Facilitate Weight Loss & Improve Health
As well as treating PCOS symptoms, Berberine can facilitate weight loss and improve blood sugar control. Berberine can lower cholesterol and blood pressure, helping to reduce metabolic health risks. Studies have also found that Berberine can inhibit infectious microorganisms, ameliorate inflammatory bowel disease, and even modify cancer cells [14].
Benefit 3: Berberine Is Better Than Metformin in Many Ways
Berberine’s best application in PCOS settings is as a substitute for metformin. There are several reasons why a substitute is needed.
In a battle of Berberine vs Metformin, Berberine usually comes out on top. Like myo-inositol, berberine performs as well as, or better, than metformin [2-4]. But it also has fewer side effects making it more attractive from a patient perspective.
Berberine is actually better than metformin for lowering cardiovascular disease risks in PCOS women. Studies show that it’s better for blood pressure and a range of metabolic biomarkers [4, 5]. Berberine may also be better for weight loss and improvements in body composition [6-8].
For PCOS women doing IVF, berberine has improved live birth rates more than metformin [8]. It can also reduce total testosterone levels [4]. This may result in small improvements to symptoms such as acne, hirsutism, and hair loss.
Best Dosage of Berberine for PCOS
Dosages of berberine depend on several factors. This includes body weight, age, and health status. But most clinical studies use between 1000 to 1500 mg per day.
Patients in these trials typically take a 500 mg dose, two or three times per day. It’s best to take berberine about 30 minutes before a meal. It’s better tolerated when taken with food. Having it before a meal may also help to blunt post-prandial blood sugar spikes.
The duration of berberine treatment depends on individual circumstances. Three months is the typical duration for many trials. This is the time needed to see changes in A1C levels. But berberine is considered safe and well-tolerated when taken for six months. Studies show that extending treatment increases the therapeutic effect [9].
Where to Buy Berberine Online
When buying supplements online, there are several things to look for. You want a reputable brand that’s open about its quality assurance processes. Obviously, you also want the best ingredients at an affordable price.
In my view, the best berberine supplement for PCOS is made by Theralogix. They use a proprietary berberine phytosome™ that’s up to 10 times more bioavailable than normal berberine. They’re also well-priced. If you purchase their product using this discount link, a daily dose costs less than $1.40.
Consistent with their reputation for producing high-quality nutraceuticals, Theralogix Berberine has also been independently tested and certified by NSF® International.
I also recommend Thorne’s Berberine product. Thorne is another highly-regarded supplement manufacturer. They have third-party certification from the TGA, the NSF, the BSCG, and the United States Pharmacopeia (USP).
Safety, Side Effects, & Interactions
Berberine is generally considered safe when taken in recommended doses. But like many of the most effective dietary supplements, there are risks to be aware of.
Berberine shouldn’t be taken when pregnant or breastfeeding unless your doctor knows about it first.
The most common side effects of berberine are GI discomfort. This includes diarrhea, constipation, and nausea. Some people also experience headaches, dizziness, and skin irritation [10].
Berberine can interact with some medications. This includes antibiotics, statins, and blood thinners. Any medication that affects the liver, might interact with berberine.
Berberine has been used for centuries in traditional medicine. But high doses may be toxic, especially for the liver and kidneys [11].
How to Enhance the Benefits of Berberine for PCOS
To get the most out of berberine, it’s best to combine it with a PCOS diet, like the one used in my free 30-Day PCOS Diet Challenge. This is because a PCOS diet also improves insulin sensitivity and reduces inflammation.
The Bottom Line
Berberine has many beneficial effects on the underlying causes of PCOS. It’s best considered as a substitute for metformin because it has powerful effects on metabolic health. It may also help with fertility and reduce symptoms such as acne, hirsutism, and hair loss.
People will often take 1000 to 1500 mg per day for three months or more. But berberine may cause gastrointestinal side effects and can interact with certain medications.
Following a PCOS diet will get you the best results possible when taking berberine for PCOS. Join my free 30-Day PCOS Diet Challenge to learn how. Or download this free 3-Day PCOS Meal Plan to get started today.
FAQ
What’s the best berberine dosage for PCOS? When taking berberine for PCOS, typical dosages are 500 mg capsules taken two or three times daily.
How long should I take berberine for PCOS? Most participants in berberine clinical trials take the supplement for three months. Extending treatment beyond this duration can improve therapeutic effects [9].
How long before I see results from berberine for PCOS? Benefits may be seen within one month of starting treatment. You should expect to take berberine for three months to see improvements in A1C levels.
Berberine vs metformin PCOS. Which is better? There is a plethora of studies that have compared berberine with metformin using a range of biomarkers. The weight of evidence indicates that berberine performs better than metformin with fewer side effects [2-8].
Can you use berberine and metformin together for PCOS? Berberine and metformin are both insulin sensitizers. This means that they do the same thing. These medicines are usually an either/or treatment. If they were taken together, the dose of metformin would need to be reduced.
Berberine PCOS weight loss. Does it help? Berberine has been shown to improve measures of body composition. This includes things like waist-to-hip ratio. It has been associated with decreased body mass index. But the strength of the effect is likely to be small [6-8].
Berberine PCOS hair loss. Does it help? Maybe a little. PCOS hair loss is a symptom of elevated androgen levels. Poor insulin regulation and chronic inflammation drive up androgen production. Berberine can help with all three of these issues [1]. By doing so, it may have an indirect impact on PCOS hair loss.
Berberine PCOS acne. Does it help? Maybe a little. Just like PCOS hair loss, PCOS acne is caused by elevated androgen levels. Berberine may be a promising new treatment for acne [12].
What is the best berberine supplement for PCOS? I recommend Theralogix Berberine or Thorne, Berberine 500 mg capsules. These are best-in-class supplement product.
Author
As a Nutritionist, I’m continuing my mission to help women like you, beat PCOS. Evidence-based diet and lifestyle interventions helped me overcome five years of infertility. I fell pregnant naturally after multiple failed IVF cycles. Along the way, my other PCOS symptoms went away too. This experience taught me how to combine the latest science with a pragmatic approach to habit change. I’ve now helped thousands of other women achieve life-changing results, and I love for you to be the next PCOS success story. Learn more about me and what I do here.
References
1Zhang, S.W., et al., Effect and mechanism of berberine against polycystic ovary syndrome. Biomed Pharmacother, 2021. 138: p. 111468.
2Mishra, N., R. Verma, and P. Jadaun, Study on the Effect of Berberine, Myoinositol, and Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomised Study. Cureus, 2022. 14(1): p. e21781.
3Li, M.F., X.M. Zhou, and X.L. Li, The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review. Evid Based Complement Alternat Med, 2018. 2018: p. 2532935.
4Xie, L., et al., The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019. 2019: p. 7918631.
5Suadoni, M.T. and I. Atherton, Berberine for the treatment of hypertension: A systematic review. Complement Ther Clin Pract, 2021. 42: p. 101287.
6Guo, J., et al., The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Oxid Med Cell Longev, 2021. 2021: p. 2074610.
7Wei, W., et al., A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol, 2012. 166(1): p. 99-105.
8An, Y., et al., The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clin Endocrinol (Oxf), 2014. 80(3): p. 425-31.
9Ye, Y., et al., Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol, 2021. 12: p. 653887.
10Imenshahidi, M. and H. Hosseinzadeh, Berberine and barberry (Berberis vulgaris): A clinical review. Phytother Res, 2019. 33(3): p. 504-523.
11Singh, N. and B. Sharma, Toxicological Effects of Berberine and Sanguinarine. Front Mol Biosci, 2018. 5: p. 21.
12Soleymani, S., et al., Promising plant-derived secondary metabolites for treatment of acne vulgaris: a mechanistic review. Arch Dermatol Res, 2020. 312(1): p. 5-23.
13Gasmi, A., et al., Berberine: Pharmacological Features in Health, Disease and Aging. Curr Med Chem, 2024. 31(10): p. 1214-1234.
14Pizzorno, J., Thinking About Berberine. Integr Med (Encinitas), 2023. 22(5): p. 6-8.
As a Nutritionist, I’m continuing my mission to help women like you, beat PCOS. Evidence-based diet and lifestyle interventions helped me overcome five years of infertility. I fell pregnant naturally after multiple failed IVF cycles. Along the way, my other PCOS symptoms went away too. This experience taught me how to combine the latest science with a pragmatic approach to habit change. I’ve now helped thousands of other women achieve life-changing results, and I love for you to be the next PCOS success story. Learn more about me and what I do here.
